Since 2004, we have developed a unique expertise in longitudinal studies of early psychosis by combining clinical, neurocognitive and neuroimaging data. This has made it possible the exploration of prognostication of outcome using neurocognition and neuroimaging data combined with symptom data. In a series of publications, we have examined remission of both positive and negative symptoms following a first episode of psychosis and identified neurocognitive and brain measures of early remission from psychosis (1). We have recently refined this work with a stronger focus on persistent negative symptoms (2). We have also systematically examined the longitudinal evolution of insight and how it relates to structural changes in the brain (3). We are still conducting longitudinal studies using a novel and high resolution imaging protocol.

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References

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(1) Bodnar et al., 2008;2012; Luck et al., 2011

(2) Benoit et al., 2012; Bodnar et al., 2014; Hovington et al., 2012;2014;2015; Lutgens et al., 2018; Makowski et al, 2016;2017;2020

(3) Buchy et al., 2015a; 2015b; 2017; 2018

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